Endocrine Abstracts

Background: Few cases have been described with a new-onset or worsening of a pre-existing diabetes mellitus in patients diagnosed with a renal cell carcinoma and amelioration of their diabetes following tumour resection.Methodology: This is a retrospective study (2003-2021) including adult cases who were diagnosed with a renal cell carcinoma, who underwent tumour resection and whom glycemic control was monitored. HbA1c was measured at 3 time intervals; 1...

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

Introduction: Tumour cachexia-anorexia syndrome (CAS) is a complex disorder characterized by progressive nutritional and metabolic alterations that lead to loss of muscle and adipose tissue observed in advanced-stage cancer. CAS indicates unfavourable prognosis, regardless of cancer type. Under the influence of permanent aggression, we have evaluated the effects of the cancer cachexia development on the hypothalamic-pituitary-adrenal (HPA) axis.Methods: ...

Introduction: Acromegaly secondary to an extrapituitary source of GH or GHRH is rare, usually associated with bronchial/thymic carcinoids, neuroendocrine enteropancreatic tumors or extrasellar somatotropinomas. Few series of acromegalic patients with negative pituitary imaging and lack of an ectopic source are reported in the literature.Methods: We report the clinical history and the laboratory and imaging results of an acromegalic woman with no clear ev...

Atrial fibrillation (AF) and, in general, cardiac arrhythmias are among the most frequent complications during clinical thyrotoxicosis. However to-day the most frequent conditions of hyperthyroidism are subclinical and more subtle is the relationship between this last condition and cardiac arrhythmias.In order to evaluate this topic, we considered two groups: A) patients admitted into the hospital for AF; B) patients affected by subclinical hyperthyroidi...

Introduction: Abnormal thyroid function is the most common disease in endocrinology and its screening of made by plasmatic (TSH), followed by (fT4) determination if abnormal. (fT3) determination is only used when pathological (TSH) and normal (fT4) are found, even if there is no evidence supporting this procedure, apart from the greater technical difficulty of measuring (fT3) due to its lower plasma concentration.Material and Methods: Observational retro...

Somatostatin analogues (SSA) represent a recognized therapeutic option in patients affected with functioning neuroendocrine tumors (NET). In non-functioning NET, SSA are reported to induce tumor stabilization in most of cases and objective response in <5%. NET associated to Multiple Endocrine Neoplasia type 1 (MEN1) are inherited tumors, generally located in the duodeno-pancreatic trait, characterized by well differentiated histotype, high expression of somatostatin recept...

Seminal plasma (SP) contains proteins secreted by testis, epididymis and male accessory glands, involved in the successful fertilization of the oocyte. The function of epididymis, prostate and seminal vesicles are dependent upon the presence of androgenic stimuli.To investigate the role of testosterone in the modulation of the proteomic pattern in SP, we analyzed human SP proteome comparing the panel of common seminal proteins in five fertile normogonada...

Introduction: Although overall accuracy of fine needle aspiration (FNA) in identifying thyroid cancer is considered excellent, 20–30% of aspirates do not allow definitive diagnosis of malignancy. Proto-oncogene somatic mutations such as BRAFV600E in FNA strongly suggest the presence of malignancy. However, only few studies reported the use of circulating BRAFV600E-mutated alleles in plasma as an useful marker for non invasive diagnosis and follow up of this disease.<p...

Background: Estrogen replacement therapy is the most effective treatment for postmenopausal (PMP) flushing, but its use is often contraindicated. An effective and safe alternative is urgently needed.Aim: To explore the effects of the LHRH receptor antagonist cetrorelix in women with severe PMP flushing who have a mean daily flush score >15.Methods: Open-label treatment with cetrorelix 250 μg twice a day in nine women with ...